Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 3/20 | 0.65 |
| ▸ | HTR2A | P28223 | 3/20 | 0.65 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831695 | 0.86 | HTR2A (0.71) | HTR1DHTR2AMTNR1AMTNR1BLMNA | |
| SCHEMBL4612891 | 0.85 | HTR2A (0.65) | HTR1DHTR2AMTNR1AMTNR1BRAB9A | |
| SCHEMBL18383116 | 0.85 | HTR1D (0.69) | HTR1DHTR2AMTNR1AMTNR1BLMNA | |
| SCHEMBL7651463 | 0.83 | HTR1D (0.67) | HTR1DHTR2AMTNR1AMTNR1BLMNA | |
| SCHEMBL31567644 | 0.81 | HTR1D (0.65) | HTR1DHTR2AMTNR1AMTNR1BLMNA | |
| SCHEMBL26636447 | 0.81 | GPR84 (0.70) | HTR1DHTR2AHTR1APCSK9MAPT | |
| SCHEMBL8344495 | 0.80 | HTR1D (0.73) | HTR1DHTR2AMTNR1AMTNR1BLMNA | |
| SCHEMBL24814500 | 0.80 | MTNR1A (0.63) | HTR1DHTR2AMTNR1AMTNR1BLMNA | |
| SCHEMBL6116786 | 0.80 | TSHR (0.69) | HTR1DHTR2AMTNR1AMTNR1BLMNA | |
| SCHEMBL699380 | 0.80 | HTR2A (0.58) | HTR1DHTR2AMTNR1AMTNR1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606887-A1 | DIINDOLYLMETHANE, PRECURSOR AND DERIVATIVES THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING LIVER DISEASES | Nanjing University (CN) | 2013-06-26 | — | — | EP | claimed |
| CN-102370638-A | Application of 3,3'-diindolylmethane and 3,3'-diindolylmethane derivatives in preparation of drugs for treating liver diseases | NANJING UNIVERSITY | 2012-03-14 | — | — | CN | claimed |
| CN-102209521-A | Hair care compositions, methods and articles of commerce that can enhance the appearance of thicker and fuller hair | PROCTER & GAMBLE | 2011-10-05 | — | — | CN | claimed |
| EP-2344114-A2 | HAIR CARE COMPOSITIONS, METHODS, AND ARTICLES OF COMMERCE THAT CAN INCREASE THE APPEARANCE OF THICKER AND FULLER HAIR | The Procter & Gamble Company (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010054343-A2 | HAIR CARE COMPOSITIONS, METHODS, AND ARTICLES OF COMMERCE THAT CAN INCREASE THE APPEARANCE OF THICKER AND FULLER HAIR | THE PROCTER & GAMBLE COMPANY (US) | 2010-05-14 | — | — | WO | claimed |
| US-20100120871-A1 | HAIR CARE COMPOSITIONS, METHODS, AND ARTICLES OF COMMERCE THAT CAN INCREASE THE APPEARANCE OF THICKER AND FULLER HAIR | THE PROCTER & GAMBLE COMPANY | 2010-05-13 | — | — | US | claimed |
| US-20040058897-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2004-03-25 | — | — | US | claimed |
| US-6605605-B2 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2003-08-12 | — | — | US | claimed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | claimed |
| US-20020058648-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2002-05-16 | — | — | US | claimed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | claimed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | claimed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | claimed |
| EP-3573960-B1 | N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES | GENFIT (FR) | 2023-08-16 | — | — | EP | disclosed |
| EP-3813766-A1 | SCALP CARE COMPOSITION WITH WELL DISPERSED PARTICULATE SCALP BENEFIT AGENTS | The Procter & Gamble Company (US) | 2021-05-05 | — | — | EP | disclosed |
| CN-112367960-A | Scalp care compositions with uniformly dispersed particulate scalp benefit agents | 宝洁公司 | 2021-02-12 | — | — | CN | disclosed |
| US-20020058648-A1 | Estrogenic substances combined with cruciferous indole compounds | HAMMERLY MILTON (US) | 2002-05-16 | — | — | US | disclosed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120871-A1 | HAIR CARE COMPOSITIONS, METHODS, AND ARTICLES OF COMMERCE THAT CAN INCREASE THE APPEARANCE OF THICKER AND FULLER HAIR | SHH, FSCN1, CUTA | HTR1D 1277/4885HTR2A 478/4885MTNR1A 2547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.