Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL659127 | 0.87 | MAPT (0.39) | SMN1; SMN2LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL658008 | 0.86 | SMN1; SMN2 (0.34) | SMN1; SMN2LMNAALDH1A1MAPTNPSR1 | |
| SCHEMBL1723899 | 0.85 | LMNA (0.33) | SMN1; SMN2LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL661032 | 0.84 | AKR1C3 (0.40) | SMN1; SMN2LMNAALDH1A1MAPTNPSR1 | |
| SCHEMBL16104249 | 0.84 | NCF1 (0.44) | SMN1; SMN2LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL659732 | 0.84 | RORC (0.34) | SMN1; SMN2LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL1721711 | 0.84 | S1PR1 (0.33) | MAPTNPSR1CHKAALOX15S1PR1 | |
| SCHEMBL657676 | 0.82 | MEN1 (0.41) | SMN1; SMN2LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL659624 | 0.82 | LMNA (0.40) | SMN1; SMN2LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL657986 | 0.81 | MAPT (0.46) | SMN1; SMN2LMNAALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406243-A1 | BENZOFURAN DERIVATIVES | Takeda Pharmaceutical Company Limited (JP) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104194-A1 | BENZOFURAN DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-16 | — | — | WO | disclosed |