Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 8/20 | 0.60 |
| ▸ | CES1 | P23141 | 9/20 | 0.58 |
| ▸ | CES2 | O00748 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | PPARD | Q03181 | 3/20 | 0.48 |
| ▸ | PPARA | Q07869 | 3/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | TLR2 | O60603 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9568273 | 0.98 | FAAH (0.61) | FAAHCES1CES2MEN1KMT2A | |
| SCHEMBL27557547 | 0.95 | FAAH (0.59) | FAAHCES1CES2MEN1KMT2A | |
| SCHEMBL1240915 | 0.92 | ALDH1A1 (0.52) | FAAHCES1CES2MEN1KMT2A | |
| Pyrrole SCHEMBL1518519 | 0.86 | FAAH (0.47) | FAAHCES1CES2MEN1KMT2A | |
| SCHEMBL28055566 | 0.83 | FAAH (0.61) | FAAHCES1CES2MEN1KMT2A | |
| SCHEMBL7614009 | 0.83 | FAAH (0.61) | FAAHCES1CES2MEN1KMT2A | |
| SCHEMBL5325729 | 0.81 | — | — | |
| SCHEMBL10715041 | 0.81 | FAAH (0.56) | FAAHCES1CES2MEN1KMT2A | |
| SCHEMBL7028971 | 0.81 | FAAH (0.59) | FAAHCES1CES2MEN1KMT2A | |
| SCHEMBL11862399 | 0.81 | FAAH (0.56) | FAAHCES1CES2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767314-A | Selective acylation of monoalkylhydrazines | ROHM AND HAAS COMPANY (US) | 1998-06-16 | — | — | US | claimed |
| US-5675037-A | REACTING UNSUBSTITUTED OR MONOALKYL-HYDRAZINES WITH TRICHLOROMETHYL ARYL KETONES | ROHM AND HAAS COMPANY (US) | 1997-10-07 | — | — | US | claimed |
| CN-1032254-C | Selective acylation of hydrazines | ROHM & HAAS (US) | 1996-07-10 | — | — | CN | claimed |
| EP-0492839-B1 | Selective acylation of hydrazines | ROHM & HAAS (US) | 1995-04-12 | — | — | EP | claimed |
| CN-1062527-A | The selectively acylating effect of hydrazine | ROHM & HAAS (US) | 1992-07-08 | — | — | CN | claimed |
| EP-0492839-A1 | Selective acylation of hydrazines | ROHM AND HAAS COMPANY (US) | 1992-07-01 | — | — | EP | claimed |
| JP-4290856-A | — | — | None | — | — | JP | disclosed |
| CN-102227261-A | Hydrogenation of ester, ketone or aldehyde groups with ruthenium complexes having di-amine and phosphorous-nitrogen bidentate ligand | FIRMENICH & CIE | 2011-10-26 | — | — | CN | disclosed |
| EP-2370207-A1 | HYDROGENATION OF ESTER, KETONE OR ALDEHYDE GROUPS WITH RUTHENIUM COMPLEXES HAVING A DI-AMINE AND A PHOSPHOROUS-NITROGEN BIDENTATE LIGAND | Firmenich S.A. (CH) | 2011-10-05 | — | — | EP | disclosed |
| US-20110190523-A1 | HYDROGENATION OF ESTERS OR CARBONYL GROUPS WITH PHOSPHINO-OXIDE BASED RUTHENIUM COMPLEXES | FIRMENICH SA (CH) | 2011-08-04 | — | — | US | disclosed |
| EP-2344276-A1 | HYDROGENATION OF ESTERS OR CARBONYL GROUPS WITH PHOSPHINO-OXIDE BASED RUTHENIUM COMPLEXES | Firmenich S.A. (CH) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010061350-A1 | HYDROGENATION OF ESTER, KETONE OR ALDEHYDE GROUPS WITH RUTHENIUM COMPLEXES HAVING A DI-AMINE AND A PHOSPHOROUS-NITROGEN BIDENTATE LIGAND | FIRMENICH SA (CH) | 2010-06-03 | — | — | WO | disclosed |
| WO-2010038209-A1 | HYDROGENATION OF ESTERS OR CARBONYL GROUPS WITH PHOSPHINO-OXIDE BASED RUTHENIUM COMPLEXES | FIRMENICH SA (CH) | 2010-04-08 | — | — | WO | disclosed |
| CN-1032254-C | Selective acylation of hydrazines | ROHM & HAAS (US) | 1996-07-10 | — | — | CN | disclosed |
| EP-0492839-B1 | Selective acylation of hydrazines | ROHM & HAAS (US) | 1995-04-12 | — | — | EP | disclosed |
| JP-H04290856-A | PRODUCTION OF MONOACYLATED HYDRAZINE | ROHM & HAAS CO | 1992-10-15 | — | — | JP | disclosed |
| CN-1062527-A | The selectively acylating effect of hydrazine | ROHM & HAAS (US) | 1992-07-08 | — | — | CN | disclosed |
| CN-1062527-A | The selectively acylating effect of hydrazine | ROHM & HAAS (US) | 1992-07-08 | — | — | CN | disclosed |
| EP-0492839-A1 | Selective acylation of hydrazines | ROHM AND HAAS COMPANY (US) | 1992-07-01 | — | — | EP | disclosed |
| EP-0492839-A1 | Selective acylation of hydrazines | ROHM AND HAAS COMPANY (US) | 1992-07-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190523-A1 | HYDROGENATION OF ESTERS OR CARBONYL GROUPS WITH PHOSPHINO-OXIDE BASED RUTHENIUM COMPLEXES | PNN, ADH5, NCL | FAAH 1788/4885CES1 1043/4885CES2 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.