Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17239751 | 0.78 | ALDH1A1 (0.44) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2746527 | 0.72 | ALDH1A1 (0.43) | ALDH1A1EPHX2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL17239775 | 0.72 | ALDH1A1 (0.41) | ALDH1A1EPHX2 | |
| SCHEMBL5000867 | 0.72 | EPHX2 (0.41) | ALDH1A1EPHX2 | |
| SCHEMBL5000757 | 0.72 | EPHX2 (0.41) | ALDH1A1EPHX2 | |
| SCHEMBL14993088 | 0.71 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL2502273 | 0.64 | ALDH1A1 (0.38) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29905932 | 0.63 | GRIN2D (0.38) | ALDH1A1EPHX2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL17239706 | 0.61 | CYP2C9 (0.33) | — | |
| SCHEMBL981922 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382267-B2 | Small molecule inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150322093-A1 | SMALL MOLECULE INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2015-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322093-A1 | SMALL MOLECULE INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | NAMPT, NAPRT, NNMT | ALDH1A1 1886/4885EPHX2 4637/4885HTT 1346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.