Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL864979 | 0.86 | HDAC8 (0.48) | HDAC8PTPN1 | |
| SCHEMBL864907 | 0.83 | ESR2 (0.48) | HDAC8PTPN1 | |
| SCHEMBL864906 | 0.83 | ESR2 (0.48) | HDAC8PTPN1 | |
| SCHEMBL7989939 | 0.83 | HDAC8 (0.48) | HDAC8PTPN1 | |
| SCHEMBL7988510 | 0.81 | UCHL1 (0.52) | HDAC8MEN1KMT2A | |
| SCHEMBL7977798 | 0.78 | HDAC8 (0.45) | HDAC8PTPN1KMT2A | |
| SCHEMBL864877 | 0.73 | DPP4 (0.50) | HDAC8PTPN1 | |
| SCHEMBL7977842 | 0.73 | DPP4 (0.64) | HDAC8PTPN1HDAC3HDAC4HDAC1 | |
| SCHEMBL7995839 | 0.73 | DPP4 (0.64) | HDAC8PTPN1HDAC3HDAC4HDAC1 | |
| SCHEMBL7989903 | 0.72 | HDAC8 (0.53) | HDAC8HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406247-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103333-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |