Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992051 | 0.86 | DPP4 (0.50) | HDAC8PTPN1 | |
| SCHEMBL7992048 | 0.86 | DPP4 (0.50) | HDAC8PTPN1 | |
| SCHEMBL864907 | 0.84 | ESR2 (0.48) | HDAC8PTPN1 | |
| SCHEMBL864906 | 0.84 | ESR2 (0.48) | HDAC8PTPN1 | |
| SCHEMBL864979 | 0.84 | HDAC8 (0.48) | HDAC8PTPN1 | |
| SCHEMBL1724314 | 0.83 | HDAC8 (0.47) | HDAC8PTPN1 | |
| SCHEMBL7988510 | 0.82 | UCHL1 (0.52) | HDAC8 | |
| SCHEMBL7977798 | 0.80 | HDAC8 (0.45) | HDAC8PTPN1USP30 | |
| SCHEMBL2898621 | 0.74 | HDAC8 (0.41) | HDAC8PTPN1 | |
| SCHEMBL7977842 | 0.74 | DPP4 (0.64) | HDAC8PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172081-B1 | DIPEPTIDYL PEPTIDASE-IV INHIBITORS; NON-INSULIN DEPENDENT DIABETES | NOVARTIS AG (CH) | 2001-01-09 | — | — | US | disclosed |