Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL864906 | 0.85 | ESR2 (0.48) | HDAC8UCHL1PTPN1HSD17B10LMNA | |
| SCHEMBL864907 | 0.85 | ESR2 (0.48) | HDAC8UCHL1PTPN1HSD17B10LMNA | |
| SCHEMBL7988510 | 0.84 | UCHL1 (0.52) | HDAC8UCHL1HSD17B10LMNANPSR1 | |
| SCHEMBL7989792 | 0.84 | DPP4 (0.51) | HDAC8 | |
| SCHEMBL7989711 | 0.84 | DPP4 (0.51) | HDAC8 | |
| SCHEMBL7989939 | 0.80 | HDAC8 (0.48) | HDAC8PTPN1USP30 | |
| SCHEMBL864979 | 0.80 | HDAC8 (0.48) | HDAC8UCHL1PTPN1 | |
| SCHEMBL5204183 | 0.79 | AGTR2 (0.51) | HDAC8PTPN1 | |
| SCHEMBL7229378 | 0.79 | AGTR2 (0.51) | HDAC8PTPN1 | |
| SCHEMBL1724314 | 0.78 | HDAC8 (0.47) | HDAC8PTPN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172081-B1 | DIPEPTIDYL PEPTIDASE-IV INHIBITORS; NON-INSULIN DEPENDENT DIABETES | NOVARTIS AG (CH) | 2001-01-09 | — | — | US | disclosed |