Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17244437 | 0.87 | ITGB3 (0.45) | ITGB3ITGA2BPDE5AHTTSMN1; SMN2 | |
| SCHEMBL7901979 | 0.83 | ITGB3 (0.55) | ITGB3ITGA2BHTTSMN1; SMN2LMNA | |
| SCHEMBL12545824 | 0.82 | ITGB3 (0.48) | ITGB3ITGA2BSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL17244438 | 0.81 | PDE5A (0.39) | ITGB3ITGA2BPDE5AKDM4EALDH1A1 | |
| SCHEMBL38662990 | 0.80 | KDM4E (0.54) | ITGB3ITGA2BSMN1; SMN2KDM4ETSHR | |
| SCHEMBL18664436 | 0.76 | DPP8 (0.47) | ITGB3ITGA2BHTTSMN1; SMN2LMNA | |
| SCHEMBL12297862 | 0.75 | TSHR (0.57) | PDE5AHTTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL2839028 | 0.73 | METAP1 (0.43) | PDE5AHTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14368231 | 0.72 | ACHE (0.45) | HTTKDM4EALDH1A1TSHRCYP3A4 | |
| SCHEMBL18664437 | 0.71 | DPP8 (0.45) | KDM4ETSHRPOLBDPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373634-B1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MOCHIDA PHARM CO LTD (JP) | 2015-11-11 | — | — | EP | disclosed |