Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (+/-)Nicotine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 4/20 | 1.00 |
| ▸ | CHRNA4 known ✓ | P43681 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | CHRNA7 | P36544 | 4/20 | 1.00 |
| ▸ | CHRNB4 | P30926 | 3/20 | 1.00 |
| ▸ | CHRNA3 | P32297 | 3/20 | 1.00 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 1.00 |
| ▸ | PSIP1 | O75475 | 1/20 | 1.00 |
| ▸ | TRPA1 | O75762 | 1/20 | 1.00 |
| ▸ | HTR3B | O95264 | 1/20 | 1.00 |
| ▸ | CHRNA1 | P02708 | 1/20 | 1.00 |
| ▸ | CHRNG | P07510 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CHRNB1 | P11230 | 1/20 | 1.00 |
| ▸ | CYP2A6 | P11509 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | CHRNA5 | P30532 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+/-)Nicotine SCHEMBL20193 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| R-Nicotine SCHEMBL20518 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL10909351 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL308101 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL11976729 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL4729900 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL10909353 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL2599622 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL797620 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL407606 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104271137-B | Nicotine oral delivery product comprising the powder being encapsulated in water-insoluble bag, wherein the powder bag includes nicotine and chewing gum compositions | 福恩伊兹有限公司 | 2019-05-10 | — | — | CN | claimed |
| US-20110305715-A1 | ANTIBODIES TO 3-HYDROXYCOTININE AND METHODS OF USE THEREOF | QUIDEL CORPORATION | 2011-12-15 | — | — | US | claimed |
| CN-117223881-A | Buccal nicotine product containing free nicotine and nicotine salt | 深圳市元雾科技有限公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-116268525-A | Nicotine salt, atomized liquid, cartridge and application thereof | 深圳市真味生物科技有限公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2020252937-A1 | APPLICATION OF HETEROCYCLIC COMPOUND EXTRACTED FROM SOLANACEAE IN PREPARING MEDICINE FOR TREATING MULTIPLE SCLEROSIS AND MEDICINE | 深圳先进技术研究院 | 2020-12-24 | — | — | WO | disclosed |
| EP-3615659-A1 | COMPOSITIONS AND METHODS FOR THE ENCAPSULATION AND SCALABLE DELIVERY OF AGROCHEMICALS | Agrospheres, Inc. (US) | 2020-03-04 | — | — | EP | disclosed |
| CN-209544825-U | Anionic generating circuit and display device | 合肥惠科金扬科技有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-110300588-A | Inhalable nicotine composite and production and preparation method thereof | 菲利普莫里斯生产公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-110283158-A | A method of recycling vegetable soda from tobacco leaching liquor | 广东省金叶科技开发有限公司 | 2019-09-27 | — | — | CN | disclosed |
| WO-2019172727-A1 | COMPOSITION FOR SMOKELESS TOBACCO AND ORALLY DISSOLVABLE FILM-TYPE SMOKELESS TOBACCO COMPRISING SAME | (주)씨엘팜 | 2019-09-12 | — | — | WO | disclosed |
| CN-209090045-U | Aerosol generates system | 深圳御烟实业有限公司 | 2019-07-12 | — | — | CN | disclosed |
| US-5135753-A | Transdermal nicotine delivery | PHARMETRIX CORPORATION (US) | 1992-08-04 | — | — | US | disclosed |
| CN-1016843-B | NICOTINE DISPENSER WITH POLYMERIC RESERVOIR OF NICOTINE | ADVANCED TOBACCO PROD (US) | 1992-06-03 | — | — | CN | disclosed |
| EP-0436599-A1 | TOBACCO SMOKE FILTERS AND PROCESS FOR PRODUCTION THEREOF | EASTMAN KODAK COMPANY (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1990003125-A1 | TOBACCO SMOKE FILTERS AND PROCESS FOR PRODUCTION THEREOF | EASTMAN KODAK COMPANY (US) | 1990-04-05 | — | — | WO | disclosed |
| US-4836224-A | CONTAINING LEVULINIC ACID | R. J. REYNOLDS TOBACCO COMPANY (US) | 1989-06-06 | — | — | US | disclosed |
| CN-86103434-A | The nicotine dispenser of band polymeric reservoir of nicotine | — | 1986-11-26 | — | — | CN | disclosed |
| US-4595024-A | Segmented cigarette | R. J. REYNOLDS TOBACCO COMPANY (US) | 1986-06-17 | — | — | US | disclosed |
| US-4469112-A | Compound filter | CELANESE CORPORATION (US) | 1984-09-04 | — | — | US | disclosed |
| US-4020850-A | Thermoplastic cigarette wrapper | BROWN & WILLIAMSON TOBACCO CORPORATION (US) | 1977-05-03 | — | — | US | disclosed |