Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nicotine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 4/20 | 1.00 |
| ▸ | CHRNA4 known ✓ | P43681 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | CHRNA7 | P36544 | 4/20 | 1.00 |
| ▸ | CHRNB4 | P30926 | 3/20 | 1.00 |
| ▸ | CHRNA3 | P32297 | 3/20 | 1.00 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 1.00 |
| ▸ | PSIP1 | O75475 | 1/20 | 1.00 |
| ▸ | TRPA1 | O75762 | 1/20 | 1.00 |
| ▸ | HTR3B | O95264 | 1/20 | 1.00 |
| ▸ | CHRNA1 | P02708 | 1/20 | 1.00 |
| ▸ | CHRNG | P07510 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CHRNB1 | P11230 | 1/20 | 1.00 |
| ▸ | CYP2A6 | P11509 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | CHRNA5 | P30532 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+/-)Nicotine SCHEMBL20193 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| R-Nicotine SCHEMBL20518 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL10909351 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL308101 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL11976729 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL4729900 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL10909353 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL1724652 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL2599622 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL797620 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461037-B1 | PROCESS FOR PREPARATION OF A BEVERAGE TREATED WITH A NICOTINE CONTAINING SUBSTANCE | KNIGHT JOSEPH ROBERT (US) | 2007-08-01 | — | — | EP | claimed |
| CN-114200032-B | Method for detecting nicotine form in tobacco material and method for judging type of acid added in tobacco material | 湖南中烟工业有限责任公司 | 2024-02-23 | — | — | CN | disclosed |
| US-20230014009-A1 | BENEFIT AGENT DELIVERY SYSTEM UTILIZING AN ELECTRIC FIELD | E INK CORPORATION | 2023-01-19 | — | — | US | disclosed |
| CN-114200032-A | Method for detecting nicotine form in tobacco material and method for judging type of acid added in tobacco material | 湖南中烟工业有限责任公司 | 2022-03-18 | — | — | CN | disclosed |
| EP-2619175-A1 | ENHANCED TRANSBUCCAL DRUG DELIVERY SYSTEM AND COMPOSITIONS | NexMed Holdings, Inc. (US) | 2013-07-31 | — | — | EP | disclosed |
| US-20130178463-A1 | ENHANCED TRANSBUCCAL DRUG DELIVERY SYSTEM AND COMPOSITIONS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2013-07-11 | — | — | US | disclosed |
| WO-2012039775-A1 | ENHANCED TRANSBUCCAL DRUG DELIVERY SYSTEM AND COMPOSITIONS | NEXMED HOLDINGS, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| US-20120017924-A1 | COATED NICOTINE-CONTAINING CHEWING GUM, MANUFACTURE AND USE THEREOF | MCNEIL AB (SE) | 2012-01-26 | — | — | US | disclosed |
| EP-1404306-B1 | A COATED NICOTINE-CONTAINING CHEWING GUM, MANUFACTURE AND USE THEREOF | MCNEIL AB (SE) | 2010-10-20 | — | — | EP | disclosed |
| EP-2152314-A1 | COATED ORAL NICOTINE FORMULATION BUFFERED WITH AMINO ACID | McNeil AB (SE) | 2010-02-17 | — | — | EP | disclosed |
| CN-100500143-C | Buluoweima slow-release tablet and its preparing method | LI ZHANG (CN) | 2009-06-17 | — | — | CN | disclosed |
| EP-2023928-A1 | COATED PHARMACEUTICAL PRODUCT FOR INTRAORAL DELIVERY OF NICOTINE COMPRISING TROMETAMOL AS BUFFERING AGENT | McNeil AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2008140372-A1 | COATED ORAL NICOTINE FORMULATION BUFFERED WITH AMINO ACID | MCNEIL AB (SE) | 2008-11-20 | — | — | WO | disclosed |
| US-20080286341-A1 | Buffered coated nicotine containing products | ANDERSSON SVEN-BORJE | 2008-11-20 | — | — | US | disclosed |
| US-7387788-B1 | Pharmaceutical compositions of nicotine and methods of use thereof | ANTARES PHARMA IPL AG (CH) | 2008-06-17 | — | — | US | disclosed |
| WO-2007133141-A1 | COATED PHARMACEUTICAL PRODUCT FOR INTRAORAL DELIVERY OF NICOTINE COMPRISING TROMETAMOL AS BUFFERING AGENT | MCNEIL AB (SE) | 2007-11-22 | — | — | WO | disclosed |
| US-20070269492-A1 | New product and use and manufacture thereof | MCNEIL-PPC, INC | 2007-11-22 | — | — | US | disclosed |
| CN-1868466-A | Buluoweima slow-release tablet and its preparing method | ZHANG LI (CN) | 2006-11-29 | — | — | CN | disclosed |
| EP-0229710-A2 | Improvements in or relating to the chemical analysis of tobacco or smoking-related products | IMPERIAL TOBACCO LIMITED (GB) | 1987-07-22 | — | — | EP | disclosed |
| US-4579858-A | AQUEOUS SOLUTION OF NICOTINE AND A THICKENING AGENT | AKTIEBOLAGET LEO (SE) | 1986-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178463-A1 | ENHANCED TRANSBUCCAL DRUG DELIVERY SYSTEM AND COMPOSITIONS | ACMSD, SLC6A6, SLC1A5 | CHRNB2 563/4885CHRNA4 1274/4885ALDH1A1 3207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.