Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of R-Nicotine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 4/20 | 1.00 |
| ▸ | CHRNA4 known ✓ | P43681 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | CHRNA7 | P36544 | 4/20 | 1.00 |
| ▸ | CHRNB4 | P30926 | 3/20 | 1.00 |
| ▸ | CHRNA3 | P32297 | 3/20 | 1.00 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 1.00 |
| ▸ | PSIP1 | O75475 | 1/20 | 1.00 |
| ▸ | TRPA1 | O75762 | 1/20 | 1.00 |
| ▸ | HTR3B | O95264 | 1/20 | 1.00 |
| ▸ | CHRNA1 | P02708 | 1/20 | 1.00 |
| ▸ | CHRNG | P07510 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CHRNB1 | P11230 | 1/20 | 1.00 |
| ▸ | CYP2A6 | P11509 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | CHRNA5 | P30532 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+/-)Nicotine SCHEMBL20193 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL10909351 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL308101 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL11976729 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL4729900 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL10909353 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL1724652 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL2599622 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL797620 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL407606 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5102 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119885110-A | ENSO-based tsutsugamushi disease space-time dynamic prediction method | 中国科学院地理科学与资源研究所 | 2025-04-25 | — | — | CN | claimed |
| US-20240390364-A1 | Novel Pyridine Compositions and their use in methods for preventing or treating diseases, disorders and conditions | REID CHRISTOPHER BRIAN (US) | 2024-11-28 | — | — | US | claimed |
| CN-116239567-B | Synthesis method of L-nicotine | 安徽中烟工业有限责任公司 | 2024-09-27 | — | — | CN | claimed |
| US-20240246929-A1 | PREPARATION METHOD OF L-NICOTINE | HUANGGANG ZY BIOTECHNOLOGY CO., LTD. (CN) | 2024-07-25 | — | — | US | claimed |
| CN-118279292-A | Black tea quality detection method and system based on feature recognition | 平利县八仙云雾茶业有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-118120876-A | Marine organism food formula and preparation method | 福建省泉州市裕园茶业有限公司 | 2024-06-04 | — | — | CN | claimed |
| EP-4366533-A1 | FUNGICIDAL USE | ADAMA MAKHTESHIM LTD. (IL) | 2024-05-15 | — | — | EP | claimed |
| CN-117814331-A | Processing method of fermented flower and red leaf tea | 滁州学院 | 2024-04-05 | — | — | CN | claimed |
| CN-117770333-A | Black tea milk tea with high LAB value and preparation method thereof | 统一企业(中国)投资有限公司昆山研究开发中心 | 2024-03-29 | — | — | CN | claimed |
| CN-117729910-A | Black tea leaf extract, composition containing black tea leaf extract and cosmetic application of black tea leaf extract | ISP投资有限公司 | 2024-03-19 | — | — | CN | claimed |
| EP-0906027-A1 | TEA PROCESSING WITH ZEOLITES | UNILEVER PLC (GB) | 1999-04-07 | — | — | EP | claimed |
| US-5863581-A | MACERATING, FERMENTING GREEN LEAF TEA, ADDING ZEOLITE BEFORE OR DURING EITHER OR BOTH OF SAID STEPS TO REACT WITH TEA TO GENERATE RED COLOR, DRYING TO FORM BLACK LEAF TEA | LIPTON, DIVISION OF CONOPCO, INC. (US) | 1999-01-26 | — | — | US | claimed |
| CN-1185808-A | Plant promoter and gene expression with the use of the same | TAKARA SHUZO CO (JP) | 1998-06-24 | — | — | CN | claimed |
| WO-1997040699-A1 | TEA PROCESSING WITH ZEOLITES | UNILEVER PLC (GB) | 1997-11-06 | — | — | WO | claimed |
| EP-0781342-A1 | PHYTOPATHOGENIC DNA VIRUS RESISTANT TRANSGENIC PLANTS AND SEEDS AND METHODS FOR OBTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1997-07-02 | — | — | EP | claimed |
| EP-0768036-A1 | Biopolymeric composition and method of preparation of a stabilized product using this | Institut für Getreideverarbeitung GmbH (DE) | 1997-04-16 | — | — | EP | claimed |
| WO-1996008573-A1 | PHYTOPATHOGENIC DNA VIRUS RESISTANT TRANSGENIC PLANTS AND SEEDS AND METHODS FOR OBTAINING SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1996-03-21 | — | — | WO | claimed |
| EP-0552519-B1 | Improvements related to tea processing | TEA PROJECTS OVERSEAS LTD (GB) | 1995-10-11 | — | — | EP | claimed |
| EP-0552519-A1 | Improvements related to tea processing | TEA PROJECTS OVERSEAS LTD. (GB) | 1993-07-28 | — | — | EP | claimed |
| US-5057422-A | RECOMBINANT DNA: TRANSFORMED MICROORGANISMS, PLANT CELLS AND PLANTS: A PROCESS FOR INTRODUCING AN INDUCIBLE PROPERTY IN PLANTS, AND A PROCESS FOR PRODUCING A POLYPEPTIDE OR PROTEIN BY MEANS OF PLANTS OR PLANT CELLS | MOGEN INTERNATIONAL N.V. (NL) | 1991-10-15 | — | — | US | claimed |