SCHEMBL17249482

SCHEMBL17249482

C[Si]1(C)C(c2ccc(-c3cccnc3)nc2)=C(c2ccccc2)C(c2ccccc2)=C1c1ccc(-c2ccccn2)nc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 6/20 0.57
CYP3A4 P08684 4/20 0.47
HPGDS O60760 1/20 0.43
PIM1 P11309 2/20 0.42
PIM2 Q9P1W9 2/20 0.42
NPC1 O15118 1/20 0.40
TP53 P04637 1/20 0.40
PKM P14618 1/20 0.40
TSHR P16473 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CYP11B1 P15538 2/20 0.40
CYP11B2 P19099 2/20 0.40
MAPT P10636 1/20 0.40
CNR2 P34972 1/20 0.39
CYP19A1 P11511 1/20 0.38
ALDH1A1 P00352 2/20 0.38
ACHE P22303 1/20 0.38
KDM4E B2RXH2 1/20 0.38
CYP2E1 P05181 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10038535 0.91 HPGDS (0.50) CYP2A6HPGDSPIM1NPC1TP53
SCHEMBL10018839 0.87 CYP2A6 (0.46) CYP2A6HPGDSMAPTCNR2CYP19A1
SCHEMBL18016432 0.84 HPGDS (0.47) CYP2A6HPGDSNPC1TP53PKM
SCHEMBL21396886 0.82 CYP2A6 (0.54) CYP2A6CYP3A4PIM1PIM2NPC1
SCHEMBL6254179 0.82 HPGDS (0.45) CYP3A4HPGDSCYP11B1CYP11B2
SCHEMBL3509967 0.82 CYP2A6 (0.85) CYP2A6CYP3A4HPGDSPIM1PIM2
SCHEMBL7116118 0.82 CYP2A6 (0.50) CYP2A6CYP3A4NPC1TP53RAB9A
SCHEMBL16189464 0.81 CYP3A4 (0.40) CYP2A6CYP3A4HPGDSNPC1PKM
SCHEMBL12114839 0.80 HPGDS (0.48) CYP2A6HPGDSPIM1NPC1TP53
SCHEMBL6256350 0.79 CYP2A6 (0.47) CYP2A6CYP3A4NPC1TP53RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9944629-B2 Material for organic electroluminescent element, organic electroluminescent element, illumination device, and display device Konica Minolta, Inc. (JP) 2018-04-17 US disclosed
US-9944629-B2 Material for organic electroluminescent element, organic electroluminescent element, illumination device, and display device Konica Minolta, Inc. (JP) 2018-04-17 US disclosed
US-20150322337-A1 MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT, ORGANIC ELECTROLUMINESCENT ELEMENT, ILLUMINATION DEVICE, AND DISPLAY DEVICE Konica Minolta, Inc. (JP) 2015-11-12 US disclosed
US-20150322337-A1 MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT, ORGANIC ELECTROLUMINESCENT ELEMENT, ILLUMINATION DEVICE, AND DISPLAY DEVICE Konica Minolta, Inc. (JP) 2015-11-12 US disclosed