SCHEMBL21396886

SCHEMBL21396886

C[Si]1(C)C(c2cccc(-c3cccnc3)n2)=C(c2ccccc2)C(c2ccccc2)=C1c1cccc(-c2ccccn2)n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 6/20 0.54
TP53 P04637 3/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
HSP90AA1 P07900 2/20 0.45
TDP1 Q9NUW8 2/20 0.45
KDM4E B2RXH2 1/20 0.45
LMNA P02545 1/20 0.45
ALPL P05186 1/20 0.45
ALPI P09923 1/20 0.45
ALPG P10696 1/20 0.45
ALOX15 P16050 1/20 0.45
MAPK1 P28482 1/20 0.45
CCR1 P32246 1/20 0.45
HTT P42858 1/20 0.45
CCR5 P51681 1/20 0.45
CCR8 P51685 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
CYP19A1 P11511 2/20 0.44
RAB9A P51151 4/20 0.43
NPC1 O15118 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13229204 0.90 KIF11 (0.47) CYP2A6TP53SMN1; SMN2HSP90AA1TDP1
SCHEMBL18385057 0.90 KDM4E (0.53) CYP2A6TP53SMN1; SMN2HSP90AA1TDP1
SCHEMBL127151 0.89 KDM4E (0.56) CYP2A6TP53SMN1; SMN2HSP90AA1TDP1
SCHEMBL10020874 0.84 CYP2A6 (0.76) CYP2A6TP53SMN1; SMN2HSP90AA1TDP1
SCHEMBL18016432 0.84 HPGDS (0.47) CYP2A6TP53SMN1; SMN2HSP90AA1TDP1
SCHEMBL17249482 0.82 CYP2A6 (0.57) CYP2A6TP53SMN1; SMN2KDM4ECYP19A1
SCHEMBL18327034 0.82 KDM4E (0.47) CYP2A6TP53SMN1; SMN2HSP90AA1TDP1
SCHEMBL13245920 0.80 KIF11 (0.55) CYP2A6SMN1; SMN2HSP90AA1LMNAHTT
SCHEMBL6252806 0.79 KMT2A (0.59) SMN1; SMN2HSP90AA1TDP1KDM4EL3MBTL1
SCHEMBL7116753 0.79 KDM4E (0.46) CYP2A6TP53SMN1; SMN2HSP90AA1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190292181-A1 COMPOSITION OF MATTER FOR USE IN ORGANIC LIGHT-EMITTING DIODES Kyulux North America, Inc. 2019-09-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190292181-A1 COMPOSITION OF MATTER FOR USE IN ORGANIC LIGHT-EMITTING DIODES CRY2, SLCO1B3, NDUFV3 CYP2A6 1276/4885TP53 671/4885SMN1; SMN2 2153/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.