Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.38 |
| ▸ | CDK4 | P11802 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CCND1 | P24385 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCND3 | P30281 | 3/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18562032 | 0.78 | CDK2 (0.56) | BRD4CDK4CCNA2CCND1CDK2 | |
| SCHEMBL17251750 | 0.76 | MAPT (0.50) | BRD4PDE4CKDM4ETSHRACHE | |
| SCHEMBL17251704 | 0.75 | PARP1 (0.49) | BRD4CDK2TP53MAPT | |
| SCHEMBL17251741 | 0.67 | PDE4C (0.40) | BRD4PDE4CKDM4ETP53MAPT | |
| SCHEMBL17251703 | 0.65 | BRD4 (0.38) | BRD4RPS6KA2PDE4CKDM4EMAPT | |
| SCHEMBL17251722 | 0.63 | CDK2 (0.53) | BRD4CDK4CCNA2CCND1CDK2 | |
| SCHEMBL28116659 | 0.63 | BRD4 (0.43) | BRD4CHEK1KDM4EPOLBTSHR | |
| SCHEMBL28116286 | 0.63 | MAPT (0.43) | BRD4KDM4EAMY1ATP53MAPT | |
| SCHEMBL28116302 | 0.62 | CHEK2 (0.42) | BRD4KDM4EPOLBTP53MAPT | |
| SCHEMBL28116663 | 0.62 | KDM4E (0.47) | CDK4CCND1KDM4ETP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015171628-A1 | COMPOUNDS FOR TREATMENT OF CANCER | GTX, INC. (US) | 2015-11-12 | — | — | WO | disclosed |