Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2762833 | 0.86 | CES1 (0.64) | LMNAABCC4GAATSHRPTGS1 | |
| SCHEMBL2898411 | 0.83 | LMNA (0.69) | LMNAABCC4GAATSHRPTGS1 | |
| SCHEMBL11879591 | 0.82 | LMNA (0.75) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL26084 | 0.82 | LMNA (1.00) | LMNAABCC4GAATSHRPTGS1 | |
| SCHEMBL23512470 | 0.81 | ALDH1A1 (0.47) | LMNAABCC4GAATSHRPTGS1 | |
| SCHEMBL15338388 | 0.81 | NPC1 (0.47) | LMNAABCC4GAATSHRPTGS1 | |
| SCHEMBL7410335 | 0.80 | LMNA (0.72) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL384892 | 0.80 | LMNA (0.95) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL8844919 | 0.80 | LMNA (0.95) | LMNAABCC4GAATSHRPTGS1 | |
| Felbinac SCHEMBL28284752 | 0.80 | LMNA (0.95) | LMNAABCC4GAATSHRPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015172047-A1 | CYCLIC PEPTIDE COMPOUNDS AND RELATED METHODS, SALTS AND COMPOSITIONS | MERCK SHARP & DOHME CORP. (US) | 2015-11-12 | — | — | WO | disclosed |