Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17319636 | 0.83 | RXRA (0.47) | RXRARXRGKIF11L3MBTL1XDH | |
| SCHEMBL130428 | 0.81 | RXRA (0.46) | RXRARXRGKIF11L3MBTL1XDH | |
| SCHEMBL172834 | 0.81 | RXRA (0.46) | RXRARXRGKIF11L3MBTL1XDH | |
| SCHEMBL2390020 | 0.81 | RXRA (0.49) | RXRARXRGKIF11L3MBTL1XDH | |
| SCHEMBL169517 | 0.81 | RXRA (0.46) | RXRARXRGKIF11L3MBTL1XDH | |
| SCHEMBL24108532 | 0.81 | RXRA (0.46) | RXRARXRGKIF11L3MBTL1XDH | |
| SCHEMBL129227 | 0.81 | RXRA (0.49) | RXRARXRGKIF11L3MBTL1XDH | |
| SCHEMBL29812995 | 0.81 | RXRA (0.46) | RXRARXRGKIF11L3MBTL1XDH | |
| SCHEMBL11984113 | 0.80 | IDO1 (0.52) | RXRARXRGIDO1TACR1CYP2D6 | |
| SCHEMBL1334073 | 0.80 | KIF11 (0.52) | RXRARXRGKIF11XDHMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979331-B1 | TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-7919506-B2 | Dibenzyl amine compounds and derivatives | PFIZER INC. (US) | 2011-04-05 | — | — | US | disclosed |