Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 16/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | ACP3 | P15309 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21495044 | 0.81 | HDAC8 (0.41) | CES2ACP3 | |
| SCHEMBL40176 | 0.81 | ACP3 (0.47) | CES2ACP3PNMT | |
| SCHEMBL12026601 | 0.78 | PTPN5 (0.48) | HSD11B1CES2ACP3PNMTPTPN5 | |
| SCHEMBL12753476 | 0.73 | HDAC4 (0.46) | HSD11B1PNMT | |
| SCHEMBL1701121 | 0.72 | ADRB1 (0.43) | — | |
| SCHEMBL1726061 | 0.72 | APP (0.36) | CES2PNMT | |
| SCHEMBL12170409 | 0.71 | CA1 (0.47) | HSD11B1 | |
| SCHEMBL13965654 | 0.70 | PTPN5 (0.46) | HSD11B1PTPN5 | |
| SCHEMBL17914398 | 0.70 | ACHE (0.50) | HSD11B1 | |
| SCHEMBL10165224 | 0.70 | HSD11B1 (0.43) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403840-A1 | DERIVATIVES OF BENZOTHIAZINES, PREPARATION THEREOF AND APPLICATION THEREOF AS DRUGS | Pierre Fabre Médicament (FR) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010100139-A1 | DERIVATIVES OF BENZOTHIAZINES, PREPARATION THEREOF AND APPLICATION THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 2010-09-10 | — | — | WO | disclosed |