Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.63 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.63 |
| ▸ | TTR | P02766 | 2/20 | 0.53 |
| ▸ | CFD | P00746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17253834 | 0.86 | GAA (0.52) | CYP4F2CYP4A11CFDGAAPTGS1 | |
| SCHEMBL17254143 | 0.86 | CYP4F2 (0.68) | CYP4F2CYP4A11TTRCFDGAA | |
| SCHEMBL8010429 | 0.85 | CYP4F2 (0.72) | CYP4F2CYP4A11CFDGAAPTGS1 | |
| SCHEMBL28092167 | 0.84 | CFD (0.49) | CYP4F2CYP4A11CFDGAAPTGS1 | |
| SCHEMBL19663053 | 0.84 | CFD (0.53) | CYP4F2CYP4A11CFDGAAPTGS1 | |
| SCHEMBL20095259 | 0.84 | CFD (0.49) | CYP4F2CYP4A11CFDGAAPTGS1 | |
| SCHEMBL19663138 | 0.83 | ALOX15 (0.54) | CYP4F2CYP4A11TTRGAATSHR | |
| SCHEMBL17253836 | 0.83 | CYP3A4 (0.50) | CYP4F2CYP4A11CFDGAAPTGS1 | |
| SCHEMBL17253828 | 0.81 | APP (0.50) | CYP4F2CYP4A11CFDGAAPTGS1 | |
| SCHEMBL27316147 | 0.81 | ALOX15 (0.53) | CYP4F2CYP4A11TTRCFDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340746-A1 | PEGYLATED CARFILZOMIB COMPOUNDS | AMGEN INC. | 2017-11-30 | — | — | US | disclosed |
| WO-2017205392-A1 | PEGYLATED CARFILZOMIB COMPOUNDS | AMGEN INC. (US) | 2017-11-30 | — | — | WO | disclosed |
| WO-2015169980-A1 | BACTERIAL STRAINS AND THE USES THEREOF IN ACYLATION AND/OR DEACYLATION REACTIONS | UNIVERSIDAD DE SEVILLA (ES) | 2015-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340746-A1 | PEGYLATED CARFILZOMIB COMPOUNDS | MCL1, FCGRT, MAN2B1 | CYP4F2 3786/4885CYP4A11 1517/4885TTR 1903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.