Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.32 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.32 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12208694 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2USP2PDK1RECQLCHRNB2 | |
| SCHEMBL12208703 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2USP2PDK1RECQL | |
| SCHEMBL12208699 | 0.83 | USP2 (0.37) | SMN1; SMN2USP2PDK1RECQL | |
| SCHEMBL12208708 | 0.80 | RECQL (0.40) | SMN1; SMN2USP2PDK1RECQL | |
| SCHEMBL12208709 | 0.80 | CHRNB2 (0.41) | SMN1; SMN2USP2PDK1RECQLCHRNB2 | |
| Hydrochloric Acid SCHEMBL4622366 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2USP2PDK1CHRNB2CHRNA3 | |
| SCHEMBL12208705 | 0.79 | RECQL (0.39) | SMN1; SMN2USP2PDK1RECQLCHRNB2 | |
| SCHEMBL12208710 | 0.79 | RBP4 (0.39) | SMN1; SMN2USP2PDK1L3MBTL1 | |
| SCHEMBL12234810 | 0.78 | SMN1; SMN2 (0.40) | SMN1; SMN2PDK1RECQLL3MBTL1 | |
| SCHEMBL17661713 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2USP2PDK1CHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403846-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. Hoffmann-La Roche AG (CH) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010100070-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-10 | — | — | WO | disclosed |