SCHEMBL12208705

SCHEMBL12208705

CC(C)(C)O[C@H]1CN(C(=O)C2CNC2)CCO1

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.39
CHRNB2 P17787 11/20 0.35
CHRNB4 P30926 11/20 0.35
CHRNA3 P32297 11/20 0.35
CHRNA4 P43681 11/20 0.35
CHRNA7 P36544 10/20 0.35
PDK1 Q15118 2/20 0.33
USP2 O75604 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
REN P00797 1/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12208708 0.84 RECQL (0.40) RECQLPDK1USP2SMN1; SMN2HPGD
SCHEMBL12233379 0.82 PDK1 (0.35) RECQLCHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL12208694 0.79 SMN1; SMN2 (0.41) RECQLCHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL1725473 0.79 SMN1; SMN2 (0.41) RECQLCHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL26125189 0.77 PDK1 (0.51) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL31655074 0.77 PDK1 (0.51) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL12208703 0.77 SMN1; SMN2 (0.38) RECQLPDK1USP2SMN1; SMN2
SCHEMBL14753009 0.77 PDK1 (0.51) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL12208699 0.76 USP2 (0.37) RECQLPDK1USP2SMN1; SMN2
SCHEMBL12331062 0.75 CHRNB2 (0.41) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130060013-A1 Compounds useful for treating neurodegenerative disorders SATORI PHARMACEUTICALS, INC. (US) 2013-03-07 US disclosed
US-20110251379-A1 COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS SATORI PHARMACEUTICALS, INC. (US) 2011-10-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130060013-A1 Compounds useful for treating neurodegenerative disorders SNCA, HTT, CLN6 RECQL 1142/4885CHRNB2 122/4885CHRNB4 152/4885
US-20110251379-A1 COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS CLN6, NLN, ACHE RECQL 528/4885CHRNB2 102/4885CHRNB4 129/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.