SCHEMBL17257331

SCHEMBL17257331

C[Si](C)(C)O/N=C/C=C/c1ccc(C#N)cc1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
LMNA P02545 2/20 0.39
GAA P10253 2/20 0.39
KDM4E B2RXH2 1/20 0.39
HDAC2 Q92769 2/20 0.38
FBP1 P09467 1/20 0.38
MAPT P10636 3/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
HTT P42858 1/20 0.38
P4HB P07237 4/20 0.37
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
SNCA P37840 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
RAB9A P51151 2/20 0.33
NPC1 O15118 1/20 0.33
CYP2A6 P11509 1/20 0.33
PLCG2 P16885 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17257335 1.00 ALDH1A1 (0.39) ALDH1A1LMNAGAAKDM4EHDAC2
SCHEMBL17257334 1.00 ALDH1A1 (0.39) ALDH1A1LMNAGAAKDM4EHDAC2
SCHEMBL17256921 0.82 ALDH1A1 (0.43) ALDH1A1LMNAGAAKDM4EHDAC2
SCHEMBL17256918 0.82 ALDH1A1 (0.43) ALDH1A1LMNAGAAKDM4EHDAC2
SCHEMBL17256924 0.82 ALDH1A1 (0.43) ALDH1A1LMNAGAAKDM4EHDAC2
SCHEMBL17256980 0.82 ALDH1A1 (0.42) ALDH1A1LMNAGAAKDM4EHDAC2
SCHEMBL17256975 0.82 ALDH1A1 (0.42) ALDH1A1LMNAGAAKDM4EHDAC2
SCHEMBL17256978 0.82 ALDH1A1 (0.42) ALDH1A1LMNAGAAKDM4EHDAC2
SCHEMBL17256937 0.80 ALDH1A1 (0.51) ALDH1A1LMNAGAAKDM4EHDAC2
SCHEMBL17256939 0.80 ALDH1A1 (0.51) ALDH1A1LMNAGAAKDM4EHDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10030083-B2 Polymers functionalized with protected oxime compounds containing a cyano group BRIDGESTONE CORPORATION (JP) 2018-07-24 US claimed
US-20150329655-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS CONTAINING A CYANO GROUP BRIDGESTONE CORPORATION (JP) 2015-11-19 US claimed
EP-3143055-B1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS CONTAINING A CYANO GROUP BRIDGESTONE CORP (JP) 2019-09-04 EP disclosed
US-10030083-B2 Polymers functionalized with protected oxime compounds containing a cyano group BRIDGESTONE CORPORATION (JP) 2018-07-24 US disclosed
EP-3143055-A2 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS CONTAINING A CYANO GROUP Bridgestone Corporation (JP) 2017-03-22 EP disclosed
US-20150329655-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS CONTAINING A CYANO GROUP BRIDGESTONE CORPORATION (JP) 2015-11-19 US disclosed
WO-2015175280-A2 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS CONTAINING A CYANO GROUP BRIDGESTONE CORPORATION (JP) 2015-11-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10030083-B2 Polymers functionalized with protected oxime compounds containing a cyano group PAM, PPOX, MB ALDH1A1 3041/4885LMNA 383/4885GAA 2104/4885
US-20150329655-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS CONTAINING A CYANO GROUP PAM, PPOX, MB ALDH1A1 3041/4885LMNA 383/4885GAA 2104/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.