Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.66 |
| ▸ | HRH1 | P35367 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | BLM | P54132 | 3/20 | 0.53 |
| ▸ | GALR3 | O60755 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | GMNN | O75496 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15132973 | 0.98 | MEN1 (0.68) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| Acetylcarnitine SCHEMBL29376874 | 0.83 | LMNA (1.00) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| Acetylcarnitine SCHEMBL2639482 | 0.83 | LMNA (1.00) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL10043020 | 0.82 | MEN1 (0.72) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| Acetylcarnitine SCHEMBL7079427 | 0.81 | LMNA (0.96) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| Acetylcarnitine SCHEMBL13323920 | 0.81 | LMNA (0.96) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL10680654 | 0.81 | LMNA (0.65) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| Acetylcarnitine SCHEMBL3259109 | 0.81 | LMNA (0.96) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL12152173 | 0.80 | LMNA (0.46) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| Acetylcarnitine SCHEMBL1651213 | 0.80 | MEN1 (0.93) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150329493-A1 | OMEGA-AMINO ACID DERIVATIVES OF BENZENE, PYRIDINE, AND PYRIDAZINE COMPOUNDS | HALL STEVEN E (US) | 2015-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329493-A1 | OMEGA-AMINO ACID DERIVATIVES OF BENZENE, PYRIDINE, AND PYRIDAZINE COMPOUNDS | LTB4R, LTB4R2, PTGER4 | CHRM2 403/4885CHRM1 252/4885LMNA 2526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.