Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254106 | 0.77 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2CYP2D6CYP2C19KDM4E | |
| SCHEMBL28392622 | 0.76 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2CYP2D6CYP2C19KDM4E | |
| SCHEMBL761379 | 0.76 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2CYP2D6CYP2C19KDM4E | |
| SCHEMBL17258949 | 0.75 | HDAC6 (0.44) | ALDH1A1SMN1; SMN2KDM4ELMNAPOLB | |
| SCHEMBL22048451 | 0.74 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2CYP2D6CYP2C19KDM4E | |
| SCHEMBL15550676 | 0.73 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2CYP2D6CYP2C19KDM4E | |
| SCHEMBL15016452 | 0.73 | L3MBTL1 (0.48) | ALDH1A1SMN1; SMN2CYP2D6CYP2C19KDM4E | |
| SCHEMBL225860 | 0.72 | CYP2D6 (0.52) | ALDH1A1SMN1; SMN2CYP2D6CYP2C19KDM4E | |
| SCHEMBL1921570 | 0.72 | CYP2D6 (0.62) | ALDH1A1SMN1; SMN2CYP2D6CYP2C19KDM4E | |
| SCHEMBL29390583 | 0.72 | CYP2D6 (0.52) | ALDH1A1SMN1; SMN2CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10022376-B2 | Pyrazolopyridines and pyrazolopyrimidines | PFIZER INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170071946-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER INC. (US) | 2017-03-16 | — | — | US | disclosed |
| US-9518052-B2 | Pyrazolopyridines and pyrazolopyrimidines | PFIZER INC. (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150329542-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER INC. | 2015-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10022376-B2 | Pyrazolopyridines and pyrazolopyrimidines | CBR3, HRH4, REN | ALDH1A1 2993/4885SMN1; SMN2 990/4885CYP2D6 257/4885 |
| US-20150329542-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | HRH2, HRH4, HRH1 | ALDH1A1 3745/4885SMN1; SMN2 697/4885CYP2D6 31/4885 |
| US-20170071946-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | HRH2, HRH4, HRH1 | ALDH1A1 3745/4885SMN1; SMN2 697/4885CYP2D6 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.