Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINA6 | P08185 | 2/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | SHBG | P04278 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.53 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.46 |
| ▸ | AR | P10275 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705296 | 0.89 | SERPINA6 (0.65) | SERPINA6SLC22A1ALDH1A1SHBGTHRB | |
| SCHEMBL12615684 | 0.86 | SERPINA6 (0.64) | SERPINA6SLC22A1ALDH1A1SHBGTHRB | |
| SCHEMBL3500490 | 0.84 | SERPINA6 (0.60) | SERPINA6SLC22A1ALDH1A1SHBGTHRB | |
| SCHEMBL15530357 | 0.84 | SERPINA6 (0.60) | SERPINA6SLC22A1ALDH1A1SHBGTHRB | |
| SCHEMBL3816344 | 0.84 | SERPINA6 (0.72) | SERPINA6SLC22A1ALDH1A1SHBGTHRB | |
| SCHEMBL16188696 | 0.82 | SHBG (0.69) | SERPINA6SLC22A1ALDH1A1SHBGTHRB | |
| SCHEMBL7615553 | 0.82 | SHBG (0.69) | SERPINA6SLC22A1ALDH1A1SHBGTHRB | |
| SCHEMBL517355 | 0.82 | SHBG (0.69) | SERPINA6SLC22A1ALDH1A1SHBGTHRB | |
| SCHEMBL16188590 | 0.82 | SHBG (0.69) | SERPINA6SLC22A1ALDH1A1SHBGTHRB | |
| SCHEMBL16741266 | 0.82 | SHBG (0.69) | SERPINA6SLC22A1ALDH1A1SHBGTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344515-B9 | METHOD AND INTERMEDIATES FOR PREPARING 2-ALKOXY AND 2-ARYLOXY ESTROGEN COMPOUNDS | NAXOSPHARMA S R L (IT) | 2013-06-26 | — | — | EP | disclosed |
| EP-2344515-B1 | METHOD AND INTERMEDIATES FOR PREPARING 2-ALKOXY AND 2-ARYLOXY ESTROGEN COMPOUNDS | NAXOSPHARMA S R L (IT) | 2013-02-13 | — | — | EP | disclosed |
| EP-2344515-A1 | METHOD AND INTERMEDIATES FOR PREPARING 2-ALKOXY AND 2-ARYLOXY ESTROGEN COMPOUNDS | Naxospharma S.R.L. (IT) | 2011-07-20 | — | — | EP | disclosed |
| US-20110130581-A1 | Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds | NAXOSPHARMA S.R.L. | 2011-06-02 | — | — | US | disclosed |
| US-7901904-B2 | Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds | NAXOSPHARMA S.R.L. (IT) | 2011-03-08 | — | — | US | disclosed |
| US-20100099141-A1 | Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds | NAXOSPHARMA S.R.L. | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130581-A1 | Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds | CYP19A1, HSD17B11, ESR1 | SERPINA6 1171/4885SLC22A1 4220/4885ALDH1A1 257/4885 |
| US-20100099141-A1 | Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds | CYP19A1, HSD17B11, ESR1 | SERPINA6 1403/4885SLC22A1 4322/4885ALDH1A1 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.