Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 5/20 | 0.69 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.69 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.60 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.60 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.60 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.50 |
| ▸ | AR | P10275 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SNCA | P37840 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL517355 | 1.00 | SHBG (0.69) | SHBGSERPINA6SLC22A1ALDH1A1THRB | |
| SCHEMBL16741266 | 1.00 | SHBG (0.69) | SHBGSERPINA6SLC22A1ALDH1A1THRB | |
| SCHEMBL7615553 | 1.00 | SHBG (0.69) | SHBGSERPINA6SLC22A1ALDH1A1THRB | |
| SCHEMBL16188696 | 1.00 | SHBG (0.69) | SHBGSERPINA6SLC22A1ALDH1A1THRB | |
| SCHEMBL3816344 | 0.90 | SERPINA6 (0.72) | SHBGSERPINA6SLC22A1ALDH1A1THRB | |
| SCHEMBL16741272 | 0.85 | SERPINA6 (0.71) | SHBGSERPINA6SLC22A1ALDH1A1THRB | |
| SCHEMBL1711107 | 0.85 | SHBG (0.68) | SHBGSERPINA6SLC22A1ALDH1A1THRB | |
| SCHEMBL7705296 | 0.85 | SERPINA6 (0.65) | SHBGSERPINA6SLC22A1ALDH1A1THRB | |
| SCHEMBL1711002 | 0.85 | SERPINA6 (0.68) | SHBGSERPINA6SLC22A1ALDH1A1THRB | |
| SCHEMBL12615684 | 0.84 | SERPINA6 (0.64) | SHBGSERPINA6SLC22A1ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4711377-A1 | STEROID COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Shujing Biopharma Co., Ltd (CN) | 2026-03-18 | — | — | EP | disclosed |
| US-11912737-B2 | 19-nor neuroactive steroids and methods of use thereof | Sage Therpeutics, Inc. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912737-B2 | 19-nor neuroactive steroids and methods of use thereof | Sage Therpeutics, Inc. (US) | 2024-02-27 | — | — | US | disclosed |
| EP-4144746-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS AND USES THEREOF | Sage Therapeutics, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |
| US-11241446-B2 | 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof | SAGE THERAPEUTICS, INC. (US) | 2022-02-08 | — | — | US | disclosed |
| EP-3909966-A1 | 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID FOR USE IN THERAPY | Sage Therapeutics, Inc. (US) | 2021-11-17 | — | — | EP | disclosed |
| EP-3498725-B1 | 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID FOR USE IN THERAPY | SAGE THERAPEUTICS INC (US) | 2021-06-09 | — | — | EP | disclosed |
| US-20210139531-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2021-05-13 | — | — | US | disclosed |
| US-20210061850-A1 | NEUROACTIVE STERIODS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. | 2021-03-04 | — | — | US | disclosed |
| US-20210061849-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. | 2021-03-04 | — | — | US | disclosed |
| US-9512165-B2 | 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof | SAGE THERAPEUTICS, INC. (US) | 2016-12-06 | — | — | US | disclosed |
| US-9512165-B2 | 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof | SAGE THERAPEUTICS, INC. (US) | 2016-12-06 | — | — | US | disclosed |
| US-20160108080-A1 | 19-NOR C3, 3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. (US) | 2016-04-21 | — | — | US | disclosed |
| US-20160108080-A1 | 19-NOR C3, 3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. (US) | 2016-04-21 | — | — | US | disclosed |
| US-20160068563-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2016-03-10 | — | — | US | disclosed |
| US-20160068563-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2016-03-10 | — | — | US | disclosed |
| WO-2014169833-A9 | 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. (US) | 2016-03-03 | — | — | WO | disclosed |
| WO-2015180679-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. (US) | 2015-12-03 | — | — | WO | disclosed |
| WO-2014169836-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. (US) | 2014-10-23 | — | — | WO | disclosed |
| WO-2014169833-A1 | 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. (US) | 2014-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108080-A1 | 19-NOR C3, 3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF | NR3C2, CYP11B1, NR3C1 | SHBG 744/4885SERPINA6 931/4885SLC22A1 1200/4885 |
| US-20210061850-A1 | NEUROACTIVE STERIODS, COMPOSITIONS, AND USES THEREOF | HSD3B1, HTR3B, HSD3B2 | SHBG 99/4885SERPINA6 677/4885SLC22A1 1149/4885 |
| US-11912737-B2 | 19-nor neuroactive steroids and methods of use thereof | NR3C2, HSD3B1, HSD3B2 | SHBG 126/4885SERPINA6 407/4885SLC22A1 549/4885 |
| US-11241446-B2 | 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof | NR3C2, NR3C1, CYP11B1 | SHBG 672/4885SERPINA6 1023/4885SLC22A1 1119/4885 |
| US-20210139531-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | NR3C2, HSD3B1, HSD3B2 | SHBG 126/4885SERPINA6 407/4885SLC22A1 549/4885 |
| US-20160068563-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | NR3C2, HSD3B1, HSD3B2 | SHBG 126/4885SERPINA6 407/4885SLC22A1 549/4885 |
| US-20210061849-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | CNR1, NR3C2, CNR2 | SHBG 208/4885SERPINA6 560/4885SLC22A1 1055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.