Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | F10 | P00742 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722897 | 0.92 | LMNA (0.45) | LMNAF10HPGDKMT2AMEN1 | |
| SCHEMBL327168 | 0.91 | LMNA (0.48) | LMNAF10HPGDKMT2AMEN1 | |
| SCHEMBL1723011 | 0.90 | LMNA (0.51) | LMNAF10HPGDKMT2AMEN1 | |
| SCHEMBL327551 | 0.89 | LMNA (0.39) | LMNAF10HPGDKMT2AMEN1 | |
| SCHEMBL303692 | 0.81 | LMNA (0.66) | LMNAHPGDKMT2AMEN1POLB | |
| SCHEMBL1723221 | 0.80 | GRM5 (0.49) | LMNAHPGDKMT2AMEN1POLB | |
| SCHEMBL18487091 | 0.80 | LMNA (0.45) | LMNAHPGDKMT2AMEN1POLB | |
| SCHEMBL303461 | 0.78 | LMNA (0.43) | LMNAHPGDKMT2AMEN1POLB | |
| SCHEMBL1722509 | 0.78 | PROKR1 (0.47) | LMNAHPGDKMT2AALDH1A1 | |
| SCHEMBL3268298 | 0.78 | HPGD (0.44) | LMNAHPGDKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | disclosed |