Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1725940 | 0.91 | LMNA (0.47) | LMNAALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL1722897 | 0.90 | LMNA (0.45) | LMNAALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL1723011 | 0.89 | LMNA (0.51) | LMNAALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL1723221 | 0.89 | GRM5 (0.49) | LMNAALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL18487091 | 0.87 | LMNA (0.45) | LMNAALDH1A1KMT2AHPGDGAA | |
| SCHEMBL303461 | 0.87 | LMNA (0.43) | LMNAALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL305968 | 0.86 | LMNA (0.42) | LMNAALDH1A1KMT2AHPGDGAA | |
| SCHEMBL1722509 | 0.86 | PROKR1 (0.47) | LMNAALDH1A1KMT2AHPGD | |
| SCHEMBL3281840 | 0.85 | KMT2A (0.51) | ALDH1A1KMT2AHPGDMEN1CNR2 | |
| SCHEMBL302862 | 0.85 | GRM5 (0.42) | LMNAALDH1A1KMT2AHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500834-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | claimed |
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | disclosed |