Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.58 |
| ▸ | JAK1 | P23458 | 6/20 | 0.58 |
| ▸ | TYK2 | P29597 | 6/20 | 0.58 |
| ▸ | JAK3 | P52333 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726928 | 0.95 | JAK2 (0.60) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL7960632 | 0.82 | JAK2 (0.61) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL29727449 | 0.78 | JAK2 (0.52) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL8906502 | 0.78 | HCAR3 (0.53) | KMT2AMAPTAGTR1AGTR2HDAC6 | |
| SCHEMBL11395129 | 0.77 | MAPT (0.75) | MAPTAGTR1AGTR2HDAC6NPC1 | |
| SCHEMBL17933567 | 0.75 | MAPT (0.72) | MAPTHDAC6NPC1 | |
| SCHEMBL23901812 | 0.74 | F2 (0.57) | JAK2JAK1TYK2JAK3F2 | |
| SCHEMBL21815430 | 0.74 | ESR1 (0.50) | KMT2AMAPTHDAC6HDAC1HDAC3 | |
| SCHEMBL34433937 | 0.74 | F2 (0.57) | JAK2JAK1TYK2JAK3F2 | |
| SCHEMBL12388321 | 0.74 | NPC1 (0.50) | MAPTAGTR1AGTR2HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403852-A1 | 3H-IMIDAZO [4, 5 -C]PYRIDINE- 6 -CARBOXAMIDES AS ANTI- INFLAMMATORY AGENTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010100249-A1 | 3H-IMIDAZO [4, 5 -C] PYRIDINE- 6 -CARBOXAMIDES AS ANTI- INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-10 | — | — | WO | disclosed |