Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.58 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727308 | 0.86 | FFAR4 (0.45) | CYP11B2FFAR4ALDH1A1CYP11B1SMN1; SMN2 | |
| SCHEMBL1721366 | 0.83 | FFAR4 (0.68) | CYP11B2FFAR4ALDH1A1CYP11B1NPC1 | |
| SCHEMBL19967147 | 0.74 | CYP11B2 (0.58) | CYP11B2FFAR4CYP11B1NPC1RAB9A | |
| SCHEMBL19965052 | 0.73 | CYP11B2 (0.56) | CYP11B2FFAR4CYP11B1NPC1RAB9A | |
| SCHEMBL1721253 | 0.73 | FFAR4 (0.60) | CYP11B2FFAR4ALDH1A1CYP11B1LMNA | |
| SCHEMBL19965197 | 0.72 | CYP11B2 (0.54) | CYP11B2FFAR4CYP11B1NPC1RAB9A | |
| SCHEMBL19965030 | 0.72 | CYP11B2 (0.54) | CYP11B2FFAR4CYP11B1NPC1RAB9A | |
| SCHEMBL1720348 | 0.70 | FFAR4 (0.56) | CYP11B2FFAR4ALDH1A1CYP11B1HTR2C | |
| SCHEMBL1721039 | 0.70 | FFAR4 (0.62) | CYP11B2FFAR4ALDH1A1CYP11B1NPC1 | |
| SCHEMBL28632326 | 0.70 | NPC1 (0.73) | CYP11B2ALDH1A1NPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406248-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104195-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-16 | — | — | WO | disclosed |