Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | PRCP | P42785 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3151303 | 0.83 | PNMT (0.45) | PNMTOPRM1OPRL1 | |
| SCHEMBL20554026 | 0.79 | PNMT (0.67) | PNMTOPRM1OPRL1PRCPADRA2A | |
| SCHEMBL14717943 | 0.79 | PNMT (0.41) | PNMTOPRM1OPRL1PRCPALDH1A1 | |
| SCHEMBL12290187 | 0.79 | PNMT (0.41) | PNMTOPRM1OPRL1PRCPALDH1A1 | |
| SCHEMBL8853554 | 0.79 | PNMT (0.71) | PNMTOPRM1OPRL1PRCPADRA2A | |
| SCHEMBL8853548 | 0.79 | PNMT (0.71) | PNMTOPRM1OPRL1PRCPADRA2A | |
| SCHEMBL13453377 | 0.77 | PNMT (0.69) | PNMTOPRM1OPRL1PRCPADRA2A | |
| SCHEMBL14355729 | 0.77 | PNMT (0.69) | PNMTOPRM1OPRL1PRCPADRA2A | |
| SCHEMBL172636 | 0.77 | PNMT (0.69) | PNMTOPRM1OPRL1PRCPADRA2A | |
| SCHEMBL7374355 | 0.76 | PNMT (0.68) | PNMTOPRM1OPRL1PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255738-B1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2012-03-07 | — | — | EP | disclosed |