Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.46 |
| ▸ | HTR2C | P28335 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885323 | 0.87 | HTR2A (0.49) | HTR2AHTR2CMAPK1TAAR1KDM4E | |
| SCHEMBL1104892 | 0.83 | HTR2A (0.46) | HTR2AHTR2CMAPK1TAAR1KDM4E | |
| SCHEMBL1104895 | 0.73 | METTL3 (0.42) | HTR2AHTR2CKDM4EALDH1A1 | |
| SCHEMBL12453534 | 0.73 | HTR2A (0.42) | HTR2AHTR2CMAPK1KDM4EALDH1A1 | |
| SCHEMBL7652993 | 0.71 | HTR2A (0.55) | HTR2AHTR2CTAAR1 | |
| SCHEMBL14037419 | 0.67 | ALDH1A1 (0.44) | KDM4EALDH1A1 | |
| SCHEMBL4474987 | 0.66 | HTR2A (0.53) | HTR2AHTR2CTAAR1KDM4EALDH1A1 | |
| SCHEMBL1104891 | 0.66 | METTL3 (0.56) | KDM4EALDH1A1 | |
| SCHEMBL15533244 | 0.65 | HTR2A (0.62) | HTR2AHTR2CTAAR1 | |
| SCHEMBL13596101 | 0.65 | HTR2A (0.52) | HTR2AHTR2CMAPK1TAAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190804-B1 | PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS | GILEAD SCIENCES INC (US) | 2015-11-18 | — | — | EP | disclosed |