Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14463410 | 1.00 | MEN1 (0.47) | MEN1KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL10943350 | 0.85 | SIGMAR1 (0.54) | MEN1KMT2ASIGMAR1ALDH1A1LTA4H | |
| SCHEMBL13995949 | 0.82 | ALDH1A1 (0.62) | MEN1KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL10863319 | 0.82 | MEN1 (0.46) | MEN1KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL13995887 | 0.82 | ALDH1A1 (0.62) | MEN1KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL19091211 | 0.82 | LMNA (0.49) | MEN1KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL104747 | 0.81 | MEN1 (0.51) | MEN1KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL22456025 | 0.81 | SIGMAR1 (0.49) | MEN1KMT2ALMNAMAPK1SIGMAR1 | |
| SCHEMBL13520306 | 0.79 | SIGMAR1 (0.48) | SIGMAR1ALDH1A1LTA4HCYP3A4CYP2D6 | |
| SCHEMBL13675825 | 0.79 | SIGMAR1 (0.70) | LMNAMAPTMAPK1SIGMAR1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255738-B1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2012-03-07 | — | — | EP | disclosed |