Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.36 |
| ▸ | HTR3B | O95264 | 3/20 | 0.36 |
| ▸ | HTR3A | P46098 | 3/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RAD51 | Q06609 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23048328 | 1.00 | SMPD3 (0.41) | SMPD3PDE10APOLBALDH1A1NPSR1 | |
| SCHEMBL25801350 | 1.00 | SMPD3 (0.41) | SMPD3PDE10APOLBALDH1A1NPSR1 | |
| SCHEMBL20128584 | 0.86 | POLB (0.38) | PDE10APOLBALDH1A1NPSR1PTPN2 | |
| SCHEMBL2162691 | 0.86 | ALDH1A1 (0.40) | PDE10APOLBALDH1A1NPSR1PTPN2 | |
| SCHEMBL12324150 | 0.86 | POLB (0.40) | PDE10APOLBALDH1A1NPSR1PTPN2 | |
| SCHEMBL18053572 | 0.83 | POLB (0.43) | PDE10APOLBALDH1A1NPSR1PTPN2 | |
| SCHEMBL25801347 | 0.81 | IKBKB (0.40) | SMPD3PDE10APOLBALDH1A1KDM4E | |
| SCHEMBL23964777 | 0.80 | POLB (0.39) | POLBPTPN2PTPN1HTR3EHTR3B | |
| SCHEMBL23048330 | 0.80 | POLB (0.39) | POLBPTPN2PTPN1HTR3EHTR3B | |
| SCHEMBL17274100 | 0.79 | ALDH1A1 (0.44) | SMPD3ALDH1A1NPSR1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218782-A1 | IMAGING METHODS USING DEUTERATED COMPOUNDS | GENENTECH, INC. (US) | 2023-07-13 | — | — | US | disclosed |
| US-20230218782-A1 | IMAGING METHODS USING DEUTERATED COMPOUNDS | GENENTECH, INC. (US) | 2023-07-13 | — | — | US | disclosed |
| US-20200297875-A1 | DEUTERATED COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-09-24 | — | — | US | disclosed |
| US-10675367-B2 | Deuterated compounds and uses thereof | GENENTECH INC. (US) | 2020-06-09 | — | — | US | disclosed |
| US-20190201561-A1 | DEUTERATED COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2019-07-04 | — | — | US | disclosed |
| US-20160250358-A1 | DEUTERATED COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-09-01 | — | — | US | disclosed |
| US-20160250358-A1 | DEUTERATED COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-09-01 | — | — | US | disclosed |
| WO-2015173225-A1 | DEUTERATED HETEROCYCLIC COMPOUNDS AND THEIR USE AS IMAGING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200297875-A1 | DEUTERATED COMPOUNDS AND USES THEREOF | SLC10A1, AVPR2, SLC9B2 | SMPD3 1032/4885PDE10A 175/4885POLB 3694/4885 |
| US-20190201561-A1 | DEUTERATED COMPOUNDS AND USES THEREOF | SLC10A1, AVPR2, SLC9B2 | SMPD3 1032/4885PDE10A 175/4885POLB 3694/4885 |
| US-20160250358-A1 | DEUTERATED COMPOUNDS AND USES THEREOF | SLC10A1, AVPR2, SLC9B2 | SMPD3 1032/4885PDE10A 175/4885POLB 3694/4885 |
| US-10675367-B2 | Deuterated compounds and uses thereof | SLC10A1, AVPR2, SLC9B2 | SMPD3 1032/4885PDE10A 175/4885POLB 3694/4885 |
| US-20230218782-A1 | IMAGING METHODS USING DEUTERATED COMPOUNDS | SLC10A1, SLC9B2, RXFP1 | SMPD3 967/4885PDE10A 224/4885POLB 3748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.