Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521241 | 0.77 | CD274 (0.51) | TSHRKMT2AMEN1CD274 | |
| SCHEMBL27418793 | 0.73 | OPRL1 (0.44) | TSHRSIGMAR1CYP3A4HSD17B10OPRL1 | |
| Hydrochloric Acid SCHEMBL27395801 | 0.72 | POLB (0.45) | KMT2AMEN1SIGMAR1CYP3A4HSD17B10 | |
| SCHEMBL831288 | 0.72 | CYP3A4 (0.53) | TSHRKMT2AMEN1SIGMAR1CYP3A4 | |
| SCHEMBL30924710 | 0.72 | SIGMAR1 (0.45) | TSHRKMT2AMEN1SIGMAR1CYP3A4 | |
| SCHEMBL22394900 | 0.70 | KMT2A (0.44) | TSHRKMT2AMEN1SIGMAR1CYP3A4 | |
| SCHEMBL26619967 | 0.70 | SIGMAR1 (0.44) | TSHRKMT2AMEN1SIGMAR1CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL7292476 | 0.69 | SIGMAR1 (0.42) | TSHRKMT2AMEN1SIGMAR1CYP3A4 | |
| SCHEMBL30665632 | 0.69 | KMT2A (0.43) | TSHRKMT2AMEN1SIGMAR1CYP3A4 | |
| SCHEMBL5592149 | 0.69 | OPRL1 (0.46) | TSHRKMT2AMEN1SIGMAR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10640494-B2 | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof | NORTHEASTERN UNIVERSITY (US) | 2020-05-05 | — | — | US | disclosed |
| US-20180222894-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof | NORTHEASTERN UNIVERSITY | 2018-08-09 | — | — | US | disclosed |
| US-9963444-B2 | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof | NORTHEASTERN UNIVERSITY (US) | 2018-05-08 | — | — | US | disclosed |
| US-20170114050-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof | NORTHEASTERN UNIVERSITY | 2017-04-27 | — | — | US | disclosed |
| EP-3145505-A1 | N-ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE (NAAA) INHIBITORS AND THEIR USE THEREOF | Northeastern University (US) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015179190-A1 | N-ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE (NAAA) INHIBITORS AND THEIR USE THEREOF | NORTHEASTERN UNIVERSITY (US) | 2015-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222894-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof | NAAA, NAT1, NAALAD2 | TSHR 2680/4885KMT2A 938/4885MEN1 357/4885 |
| US-10640494-B2 | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof | NAAA, NAT1, NAALAD2 | TSHR 2680/4885KMT2A 938/4885MEN1 357/4885 |
| US-20170114050-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof | NAAA, NAT1, NIT2 | TSHR 2507/4885KMT2A 880/4885MEN1 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.