Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10355477 | 0.83 | ALDH1A1 (0.41) | OPRL1KMT2APOLBDRD2ALDH1A1 | |
| SCHEMBL8936204 | 0.83 | OPRL1 (0.46) | OPRL1MEN1KMT2APOLBCYP3A4 | |
| SCHEMBL3272543 | 0.82 | MEN1 (0.47) | OPRL1MEN1KMT2APOLBCYP3A4 | |
| SCHEMBL24696382 | 0.81 | OPRL1 (0.45) | OPRL1MEN1KMT2APOLBCYP3A4 | |
| SCHEMBL2931788 | 0.81 | MEN1 (0.46) | OPRL1MEN1KMT2APOLBCYP3A4 | |
| SCHEMBL14234878 | 0.80 | CYP2D6 (0.50) | OPRL1MEN1KMT2APOLBCYP3A4 | |
| SCHEMBL9301631 | 0.79 | MEN1 (0.45) | MEN1KMT2APOLBCYP3A4HSD17B10 | |
| SCHEMBL207170 | 0.79 | OPRL1 (0.49) | OPRL1MEN1KMT2APOLBCYP3A4 | |
| SCHEMBL26619967 | 0.77 | SIGMAR1 (0.44) | OPRL1MEN1KMT2APOLBCYP3A4 | |
| SCHEMBL25000121 | 0.77 | CYP2D6 (0.43) | OPRL1MEN1KMT2APOLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117482-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | claimed |
| WO-2007117482-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |