Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025864 | 0.81 | KDR (0.64) | KDRCHEK1RAB9ANPC1MAPT | |
| SCHEMBL1414455 | 0.80 | KDR (0.59) | KDRCHEK1RAB9ANPC1MAPT | |
| SCHEMBL29370693 | 0.77 | KDR (1.00) | KDRCHEK1RAB9ANPC1MAPT | |
| SCHEMBL5076094 | 0.77 | KDR (1.00) | KDRCHEK1RAB9ANPC1MAPT | |
| SCHEMBL935681 | 0.75 | KDR (0.65) | KDRCHEK1RAB9ANPC1MAPT | |
| SCHEMBL10997079 | 0.74 | RAB9A (0.71) | KDRCHEK1RAB9ANPC1MAPT | |
| SCHEMBL11551230 | 0.74 | KDM4E (0.68) | KDRCHEK1RAB9ANPC1MAPT | |
| SCHEMBL10997076 | 0.73 | NPC1 (0.92) | KDRCHEK1RAB9ANPC1MAPT | |
| 2-Phenyl-1H-Indole SCHEMBL29363616 | 0.73 | NPC1 (1.00) | KDRCHEK1RAB9ANPC1MAPT | |
| 2-Phenyl-1H-Indole SCHEMBL341378 | 0.73 | NPC1 (1.00) | KDRCHEK1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230340412-A1 | Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood | IOVANCE BIOTHERAPEUTICS INC (US) | 2023-10-26 | — | — | US | disclosed |
| US-20230340412-A1 | Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood | IOVANCE BIOTHERAPEUTICS INC (US) | 2023-10-26 | — | — | US | disclosed |
| US-20220118011-A1 | PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IMMUNOTHERAPY | IOVANCE BIOTHERAPEUTICS, INC. | 2022-04-21 | — | — | US | disclosed |
| US-20200347350-A1 | Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood | IOVANCE BIOTHERAPEUTICS INC (US) | 2020-11-05 | — | — | US | disclosed |
| US-20200224161-A1 | EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND THERAPEUTIC USES THEREOF | IOVANCE BIOTHERAPEUTICS, INC. | 2020-07-16 | — | — | US | disclosed |
| EP-1919891-B1 | 3,5-DISUBSTITUTED PYRID-2-ONES USEFUL AS INHIBITORS OF TEC FAMILY OF NON-RECEPTOR TYROSINE KINASES | VERTEX PHARMA (US) | 2012-03-07 | — | — | EP | disclosed |
| US-7691885-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-06 | — | — | US | disclosed |
| US-7691885-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-06 | — | — | US | disclosed |
| US-20070155794-A1 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-07-05 | — | — | US | disclosed |
| US-20070155794-A1 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-07-05 | — | — | US | disclosed |
| WO-2007027594-A1 | 3,5-DISUBSTITUTED PYRID-2-ONES USEFUL AS INHIBITORS OF TEC FAMILY OF NON-RECEPTOR TYROSINE KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200224161-A1 | EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND THERAPEUTIC USES THEREOF | PBK, MALT1, BCL9L | KDR 293/4885CHEK1 2758/4885RAB9A 3244/4885 |
| US-20230340412-A1 | Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood | LTK, LIFR, PBK | KDR 99/4885CHEK1 3424/4885RAB9A 3473/4885 |
| US-20200347350-A1 | Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood | LTK, LIFR, PBK | KDR 99/4885CHEK1 3424/4885RAB9A 3473/4885 |
| US-20070155794-A1 | Pyridones useful as inhibitors of kinases | MAP3K20, MAP3K6, MAP3K5 | KDR 1496/4885CHEK1 106/4885RAB9A 2776/4885 |
| US-20220118011-A1 | PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IMMUNOTHERAPY | ICOS, PBK, IL2 | KDR 1379/4885CHEK1 3710/4885RAB9A 4708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.