Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.46 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3035979 | 0.82 | LTA4H (0.70) | LTA4HCHRM4UTS2RSLC2A1 | |
| SCHEMBL3035981 | 0.82 | LTA4H (0.70) | LTA4HCHRM4UTS2RSLC2A1 | |
| SCHEMBL1729486 | 0.82 | HRH3 (0.48) | LTA4HMCHR1KCNH2MCHR2 | |
| SCHEMBL1728816 | 0.79 | KDM4E (0.47) | LTA4HMCHR1KCNH2 | |
| SCHEMBL1727502 | 0.78 | MAOB (0.48) | LTA4HCHRM4SLC2A1 | |
| SCHEMBL1728669 | 0.77 | LTA4H (0.68) | LTA4HMCHR1KCNH2 | |
| SCHEMBL1728748 | 0.76 | MCHR1 (0.66) | LTA4HMCHR1KCNH2 | |
| SCHEMBL1728610 | 0.75 | KCNH2 (0.57) | LTA4HMCHR1KCNH2 | |
| SCHEMBL1728694 | 0.74 | KDM4E (0.56) | LTA4HMCHR1KCNH2MCHR2 | |
| SCHEMBL6081884 | 0.74 | TMEM97 (0.60) | LTA4HMCHR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |