Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | LTA4H | P09960 | 2/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728503 | 0.89 | LTA4H (0.54) | KDM4ELTA4HHRH3SIGMAR1MCHR1 | |
| SCHEMBL1728674 | 0.86 | ALDH1A1 (0.60) | KDM4ELTA4HHRH3ALDH1A1MCHR1 | |
| SCHEMBL6081709 | 0.86 | TMEM97 (0.69) | KDM4ELTA4HHRH3SIGMAR1ALDH1A1 | |
| SCHEMBL6081461 | 0.85 | HRH3 (0.52) | LTA4HHRH3SIGMAR1MCHR1KCNH2 | |
| SCHEMBL1727661 | 0.85 | LTA4H (0.60) | LTA4HHRH3MCHR1KCNH2MCHR2 | |
| SCHEMBL1729486 | 0.84 | HRH3 (0.48) | LTA4HHRH3SIGMAR1MCHR1KCNH2 | |
| SCHEMBL1728438 | 0.84 | LTA4H (0.56) | LTA4HHRH3MCHR1KCNH2MCHR2 | |
| SCHEMBL1729757 | 0.84 | LTA4H (0.53) | LTA4HHRH3MCHR1KCNH2MCHR2 | |
| SCHEMBL6083117 | 0.84 | DRD2 (0.59) | LTA4HHRH3SIGMAR1MCHR1KCNH2 | |
| SCHEMBL1727579 | 0.83 | SIGMAR1 (0.52) | KDM4EHRH3SIGMAR1MCHR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |