Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728610 | 0.90 | KCNH2 (0.57) | MCHR1KCNH2TSHRLTA4HACHE | |
| SCHEMBL1728135 | 0.87 | LTA4H (0.51) | MCHR1KCNH2TSHRLTA4H | |
| SCHEMBL6081348 | 0.87 | LTA4H (0.51) | MCHR1KCNH2TSHRLTA4H | |
| SCHEMBL1728669 | 0.87 | LTA4H (0.68) | MCHR1KCNH2LTA4HKDM4EALDH1A1 | |
| SCHEMBL1728580 | 0.85 | LTA4H (0.51) | MCHR1KCNH2LTA4HALDH1A1MEN1 | |
| SCHEMBL1729935 | 0.81 | MCHR1 (0.45) | MCHR1KCNH2LTA4HMEN1KMT2A | |
| SCHEMBL1728641 | 0.81 | GNRHR (0.48) | MCHR1KCNH2TSHRLTA4HKDM4E | |
| SCHEMBL1728493 | 0.80 | MCHR1 (0.78) | MCHR1KCNH2LTA4H | |
| SCHEMBL1728658 | 0.80 | LTA4H (0.70) | MCHR1KCNH2LTA4H | |
| SCHEMBL2893078 | 0.80 | MCHR1 (1.00) | MCHR1KCNH2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |