Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21339535 | 0.84 | SCN9A (0.37) | DHODHLMNAL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL14305542 | 0.81 | GAA (0.39) | LMNAL3MBTL1KDM4EALDH1A1GLA | |
| SCHEMBL14303603 | 0.81 | NR4A1 (0.48) | DHODHKDM4CLMNAALDH1A1GAA | |
| SCHEMBL287761 | 0.79 | LMNA (0.47) | HCAR2LMNAL3MBTL1ALDH1A1GLA | |
| SCHEMBL14076853 | 0.79 | ALDH1A1 (0.39) | HCAR2KDM4CKDM4EALDH1A1HCAR3 | |
| SCHEMBL12079620 | 0.79 | AGBL2 (0.40) | HCAR2KDM4CKDM4EALDH1A1HCAR3 | |
| SCHEMBL23413510 | 0.77 | LMNA (0.46) | HCAR2LMNAL3MBTL1ALDH1A1GLA | |
| Hydrochloric Acid SCHEMBL20139726 | 0.77 | LMNA (0.46) | HCAR2LMNAL3MBTL1ALDH1A1GLA | |
| SCHEMBL287320 | 0.76 | HCAR2 (0.42) | DHODHHCAR2LMNAL3MBTL1KDM4E | |
| SCHEMBL15268202 | 0.76 | RECQL (0.42) | DHODHLMNAALDH1A1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2175859-B1 | FUSED HETEROARYL PYRIDYL AND PHENYL BENZENESULFONAMIDES AS CCR2 MODULATORS FOR THE TREAMENT OF INFLAMMATION | CHEMOCENTRYX INC (US) | 2012-03-07 | — | — | EP | disclosed |