Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17277514 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2DRD2DRD4TDP1L3MBTL1 | |
| SCHEMBL29690388 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2DRD2DRD4TDP1L3MBTL1 | |
| SCHEMBL7144506 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2DRD2DRD4TDP1L3MBTL1 | |
| SCHEMBL18295355 | 0.82 | ADRB2 (0.56) | SMN1; SMN2L3MBTL1ADRB2ADRB1KMT2A | |
| SCHEMBL9124730 | 0.82 | ADRB2 (0.56) | SMN1; SMN2L3MBTL1ADRB2ADRB1KMT2A | |
| SCHEMBL18295358 | 0.82 | ADRB2 (0.56) | SMN1; SMN2L3MBTL1ADRB2ADRB1KMT2A | |
| SCHEMBL27465 | 0.81 | DRD2 (0.62) | SMN1; SMN2DRD2DRD4TDP1L3MBTL1 | |
| SCHEMBL29381067 | 0.81 | DRD2 (0.62) | SMN1; SMN2DRD2DRD4TDP1L3MBTL1 | |
| SCHEMBL17286558 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2DRD2DRD4TDP1L3MBTL1 | |
| SCHEMBL29083526 | 0.80 | DRD2 (0.61) | SMN1; SMN2DRD2DRD4TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488525-B1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS INC (US) | 2018-04-25 | — | — | EP | disclosed |
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |