Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUAK1 | O60285 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | NEK2 | P51955 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.54 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17280359 | 0.84 | KDM4E (0.53) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL15932525 | 0.83 | KDM4E (0.65) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL17280388 | 0.81 | NUAK1 (0.43) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL17280355 | 0.81 | KDM4E (0.59) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL17280370 | 0.80 | MEN1 (0.53) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL17280352 | 0.79 | KDM4E (0.69) | KDM4EMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL17280364 | 0.79 | KDM4E (0.52) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL17280377 | 0.79 | KDM4E (0.49) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL17280381 | 0.79 | ALDH1A1 (0.49) | NUAK1IGF1RMETPIM1SRC | |
| SCHEMBL3682437 | 0.79 | NUAK1 (0.58) | NUAK1IGF1RMETPIM1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650355-B2 | Method for preparation of justicidin a derivatives of arylnaphthalene lignan structure | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2017-05-16 | — | — | US | disclosed |
| US-20150336938-A1 | METHOD FOR PREPARATION OF JUSTICIDIN A DERIVATIVES OF ARYLNAPHTHALENE LIGNAN STRUCTURE | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2015-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336938-A1 | METHOD FOR PREPARATION OF JUSTICIDIN A DERIVATIVES OF ARYLNAPHTHALENE LIGNAN STRUCTURE | UGT1A8, NOTUM, MLN | NUAK1 2314/4885IGF1R 3121/4885MET 3773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.