Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 12/20 | 0.59 |
| ▸ | HTR3A | P46098 | 10/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828780 | 0.88 | HTR4 (0.75) | HTR4HTR3A | |
| SCHEMBL29400525 | 0.88 | HTR4 (0.75) | HTR4HTR3A | |
| SCHEMBL1728189 | 0.84 | HTR4 (0.59) | HTR4HTR3A | |
| SCHEMBL1728218 | 0.83 | HTR4 (0.63) | HTR4HTR3A | |
| SCHEMBL1727585 | 0.81 | HTR4 (0.59) | HTR4HTR3A | |
| SCHEMBL1726614 | 0.81 | HTR4 (0.59) | HTR4HTR3A | |
| SCHEMBL1726873 | 0.77 | HTR4 (0.48) | HTR4HTR3ALMNA | |
| SCHEMBL1728620 | 0.76 | HTR4 (0.49) | HTR4HTR3A | |
| Felcisetrag SCHEMBL390795 | 0.75 | HTR4 (1.00) | HTR4HTR3A | |
| Felcisetrag SCHEMBL4361880 | 0.74 | HTR4 (0.98) | HTR4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899324-B1 | Benzimidazole-carboxamide compounds as 5-HT4 receptor agonists | THERAVANCE INC (US) | 2011-11-30 | — | — | EP | claimed |