Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 10/20 | 0.48 |
| ▸ | HTR3A | P46098 | 9/20 | 0.48 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728116 | 0.90 | HTR3A (0.45) | HTR4HTR3APARP1HTR2AHTR2C | |
| SCHEMBL829163 | 0.89 | HTR4 (0.60) | HTR4HTR3APARP1PARP2 | |
| SCHEMBL29399928 | 0.89 | HTR4 (0.60) | HTR4HTR3APARP1PARP2 | |
| SCHEMBL1728203 | 0.85 | HTR3A (0.44) | HTR4HTR3APARP1HSD11B1AKR1C3 | |
| SCHEMBL1728189 | 0.81 | HTR4 (0.59) | HTR4HTR3APARP1HTR2AHTR2C | |
| SCHEMBL29401326 | 0.80 | HTR3A (0.59) | HTR4HTR3APARP1PARP2 | |
| SCHEMBL828636 | 0.80 | HTR3A (0.59) | HTR4HTR3APARP1PARP2 | |
| SCHEMBL1728218 | 0.79 | HTR4 (0.63) | HTR4HTR3APARP1CYP2C9CYP2C19 | |
| SCHEMBL829424 | 0.77 | HTR4 (0.76) | HTR4HTR3APARP1PARP2 | |
| SCHEMBL1728064 | 0.77 | HTR4 (0.59) | HTR4HTR3ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899324-B1 | Benzimidazole-carboxamide compounds as 5-HT4 receptor agonists | THERAVANCE INC (US) | 2011-11-30 | — | — | EP | claimed |