Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.53 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 8/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | DDX3X | O00571 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15548150 | 0.87 | SMN1; SMN2 (0.58) | NFATC1GSK3BDYRK1AKDRPDGFRA | |
| SCHEMBL17282298 | 0.86 | DYRK1A (0.48) | IMPDH2NFATC1GSK3BDYRK1AKDR | |
| SCHEMBL15550098 | 0.83 | DYRK1A (0.63) | NFATC1GSK3BDYRK1AS1PR1S1PR3 | |
| SCHEMBL15548085 | 0.77 | DYRK1A (0.42) | IMPDH2NFATC1GSK3BDYRK1APDGFRA | |
| SCHEMBL15547534 | 0.75 | AHR (0.56) | KDRPDGFRAMAPTRAB9AKMT2A | |
| SCHEMBL17286122 | 0.75 | DYRK1A (0.55) | NFATC1GSK3BDYRK1AMAP4K4S1PR1 | |
| SCHEMBL17282300 | 0.73 | AHR (0.48) | NFATC1GSK3BDYRK1AKDRPDGFRA | |
| SCHEMBL17282297 | 0.73 | DYRK1A (0.79) | NFATC1GSK3BDYRK1AKDR | |
| SCHEMBL20379377 | 0.71 | NAMPT (0.53) | MAPTRAB9AKMT2ANPC1MEN1 | |
| SCHEMBL1880857 | 0.71 | MAP2 (0.62) | IMPDH2KDRKITPDGFRAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MERCK SHARPE & DOHME CORP. | 2015-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MAPT, SLC14A1, UBTF | IMPDH2 566/4885NFATC1 3349/4885GSK3B 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.