Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.48 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17282299 | 0.86 | IMPDH2 (0.53) | DYRK1ANFATC1GSK3BIMPDH2S1PR1 | |
| SCHEMBL15548150 | 0.76 | SMN1; SMN2 (0.58) | DYRK1ANFATC1GSK3BMEN1KMT2A | |
| SCHEMBL15550098 | 0.73 | DYRK1A (0.63) | DYRK1ANFATC1GSK3BS1PR1S1PR3 | |
| SCHEMBL15548085 | 0.70 | DYRK1A (0.42) | DYRK1ANFATC1GSK3BIMPDH2S1PR1 | |
| SCHEMBL15547534 | 0.69 | AHR (0.56) | MEN1KMT2ALMNAMAPTKDR | |
| SCHEMBL17282300 | 0.69 | AHR (0.48) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL17282297 | 0.67 | DYRK1A (0.79) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 | |
| SCHEMBL17286122 | 0.66 | DYRK1A (0.55) | DYRK1ANFATC1GSK3BS1PR1S1PR3 | |
| SCHEMBL20379377 | 0.64 | NAMPT (0.53) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL15547185 | 0.64 | DYRK1A (0.77) | DYRK1ANFATC1GSK3BPDPK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MERCK SHARPE & DOHME CORP. | 2015-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MAPT, SLC14A1, UBTF | DYRK1A 2261/4885NFATC1 3349/4885GSK3B 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.