Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 7/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKLR | P30613 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23215085 | 0.81 | OPRL1 (0.42) | OPRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL17285882 | 0.81 | EGFR (0.46) | OPRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL21078109 | 0.81 | OPRL1 (0.40) | OPRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL11213153 | 0.80 | OPRL1 (0.58) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL20069796 | 0.79 | ALDH1A1 (0.59) | OPRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL17281949 | 0.78 | OPRM1 (0.47) | OPRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL28206644 | 0.77 | CYP17A1 (0.37) | OPRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL11205205 | 0.77 | CCR3 (0.57) | OPRL1OPRM1OPRD1OPRK1CCR3 | |
| SCHEMBL16549503 | 0.77 | ALDH1A1 (0.48) | OPRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL20147690 | 0.77 | OPRM1 (0.51) | OPRL1OPRM1OPRD1OPRK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015177326-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-11-26 | — | — | WO | disclosed |