Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10077960 | 0.83 | ALDH1A1 (0.59) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL21077933 | 0.83 | ALDH1A1 (0.59) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL17886583 | 0.81 | ALDH1A1 (0.57) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL23722370 | 0.80 | ALDH1A1 (0.55) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL30919794 | 0.80 | ALDH1A1 (0.55) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL23231710 | 0.80 | ALDH1A1 (0.55) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL3441676 | 0.80 | ALDH1A1 (0.75) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL10057647 | 0.80 | OPRM1 (0.59) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL9616977 | 0.79 | ALDH1A1 (0.54) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL17284231 | 0.79 | OPRL1 (0.40) | ALDH1A1LMNAPOLBOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |