Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.60 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22878464 | 0.87 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3LSSACHE | |
| SCHEMBL17285893 | 0.87 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3LSSACHE | |
| SCHEMBL17282146 | 0.85 | SLC6A2 (0.59) | SLC6A2SLC6A4SLC6A3LSSACHE | |
| SCHEMBL17284204 | 0.82 | GRIN2B (0.51) | SIGMAR1 | |
| SCHEMBL17284599 | 0.80 | LTA4H (0.55) | — | |
| SCHEMBL17284454 | 0.79 | SIGMAR1 (0.55) | SLC6A2SLC6A4SLC6A3SIGMAR1KCNH2 | |
| SCHEMBL17284490 | 0.78 | SIGMAR1 (0.48) | SIGMAR1PYCR1 | |
| SCHEMBL17284457 | 0.77 | HRH3 (0.49) | LSS | |
| SCHEMBL17284455 | 0.77 | HRH3 (0.49) | SLC6A2SLC6A4SLC6A3SIGMAR1KCNH2 | |
| SCHEMBL17284449 | 0.76 | SLC6A2 (0.46) | SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015177326-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-11-26 | — | — | WO | disclosed |