Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 14/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 14/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.61 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.45 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17285893 | 0.89 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3LSSACHE | |
| SCHEMBL17284458 | 0.87 | SLC6A2 (0.60) | SLC6A2SLC6A4SLC6A3LSSACHE | |
| SCHEMBL17282146 | 0.86 | SLC6A2 (0.59) | SLC6A2SLC6A4SLC6A3LSSACHE | |
| SCHEMBL22878155 | 0.82 | GRIN2B (0.52) | SIGMAR1 | |
| SCHEMBL22878293 | 0.79 | LTA4H (0.56) | — | |
| SCHEMBL22878359 | 0.78 | SIGMAR1 (0.56) | SLC6A2SLC6A4SLC6A3SIGMAR1KCNH2 | |
| SCHEMBL22878388 | 0.77 | SIGMAR1 (0.49) | SIGMAR1PYCR1 | |
| SCHEMBL22878383 | 0.76 | HRH3 (0.50) | LSS | |
| SCHEMBL22878360 | 0.76 | HRH3 (0.50) | PYCR1 | |
| SCHEMBL22878462 | 0.75 | NOS3 (0.46) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145929-B1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-13 | — | — | EP | disclosed |